Lesion Segmentation Tool (LST)

For many pathological MRI applications it is necessary to segment out T2 hyperintense lesions from FLAIR scans. LST provides algorithms to do this automatically. LST is based on SPM12 and has two alorithms LGA (lesion growth algorithm) and LPA (lesion prediction algorithm). LGA requires a T1 and FLAIR scan. LPA is newer and requires only a FLAIR scan. This paper looks at both in the context of MS lesion segmentation:

Egger et al. (2017). MRI FLAIR lesion segmentation in multiple sclerosis: Does automated segmentation hold up with manual annotation? NeuroImage. Clinical, 13, 264–270. http://doi.org/10.1016/j.nicl.2016.11.020

LST requires SPM12 within MATLAB. Please see download and install instructions on the relevant websites.

LST has comprehensive documentation here: https://www.applied-statistics.de/LST_documentation.pdf